Biomarker Panel Analysis
Measuring pharmacodynamic response
When the administration of a drug disturbs amino acid physiology in a tissue, it becomes a useful pharmacodynamic (PD) biomarker for assessment of drug action. A biomarker panel analysis allows you to measure multiple PD responses at once, which can provide an early read on compound efficacy. This supports better decision-making, which translates into shorter development times and more efficient use of development dollars.
Why Choose ABC?
Biomarker panel analysis involves evaluating dozens of analytes of interest—analytes that happen to be endogenous to your samples. Consequently, accurate analysis and interpretation of your drug's biomarker panel requires a great deal of analytical expertise. It also requires robust physiological Amino Acid or ELISA-based methods—preferably methods developed in a laboratory with rigorous quality systems and processes. When you send your biomarker panel to ABC Laboratories, our expert analytical team draws on their decades of amino acid and analytical experience to develop and validate reliable, robust biomarker methods.
In addition, biomarker panel assays require a variety of technologies many CROs can't offer, but ABC maintains the full spectrum of analytical instrumentation, including Meso Scale Discovery's SECTOR® Imager 6000 electrochemiluminescence (ECL) and SpectraMax® Plus 96/384 plate readers for ELISA-based testing, and the Waters® UPLC platform for physiological AAA analysis.
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