In-vitro DMPK Services GLP and non-GLP Program Support ABC Laboratories provides GLP and non-GLP services for preclinical in-vitro and in-vivo programs. Our drug metabolism and pharmacokinetics experts reliably quantify and interpret results to put IND-enabling programs on the fast track. ABC's unique combination of radio-labeling expertise, in-vitro DMPK study design and execution, and a partnership with a leading cellular/subcellular service provider enables us to streamline preclinical programs, expediting the path to first-in-human studies. Metabolic Stability Interspecies Comparisons Metabolism (S9, Microsomal, Hepatocytes) Metabolite Profiling and Identification (Proposed Metabolic Pathway) Cytochrome P450 Inhibition IC50 and Ki Determinations Mechanism-based Inhibition Validated LC-MS/MS Methods Cytochrome P450 Induction (ex-vivo and in-vitro) LC-MS/MS Method for P450 Activity Cytochrome P450 Reaction Phenotyping Correlation Analysis Chemical/Antibody Inhibition cDNA Expressed Enzymes Drug-Drug Interactions In-vitro evaluation of drug-drug interactions Analytical Method Development (HPLC or LC-MS/MS) Protein Binding (in-vitro and in-vivo samples) Equilibrium Dialysis Ultrafiltration Ultracentrifugation Data Acquisition/Reporting Analyst Win NonLin Sigmastat Empower 2 Daily backup of raw data Detailed, customized reports & electronic reporting available ABC Laboratories combines in-house metabolism expertise with industry-leading cellular and subcellular products and services to efficiently deliver complete in-vitro DMPK programs.